pI: 7.8307 |
Length (AA): 310 |
MW (Da): 33556 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_137810)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G45490 | serine/threonine-protein kinase aurora-3 |
Caenorhabditis elegans | CELE_K07C11.2 | Protein AIR-1 |
Leishmania braziliensis | LbrM.26.2370 | protein kinase, putative |
Leishmania donovani | LdBPK_262460.1 | protein kinase, putative |
Leishmania infantum | LinJ.26.2460 | protein kinase, putative |
Leishmania major | LmjF.26.2440 | protein kinase, putative |
Leishmania mexicana | LmxM.26.2440 | protein kinase, putative |
Oryza sativa | 4334220 | Os03g0765000 |
Trypanosoma brucei gambiense | Tbg972.9.370 | protein kinase, putative |
Trypanosoma brucei | Tb11.v5.0874 | protein kinase, putative |
Trypanosoma brucei | Tb927.9.1670 | Aurora kinase 3, putative |
Trypanosoma congolense | TcIL3000_9_260 | protein kinase, putative |
Trypanosoma cruzi | TcCLB.506715.10 | Aurora kinase 3, putative |
Trypanosoma cruzi | TcCLB.510349.80 | Aurora kinase 3, putative |
Trypanosoma cruzi | TcCLB.504655.30 | protein kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K07C11.2 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_K07C11.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K07C11.2 | Caenorhabditis elegans | sterile | wormbase |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.